4D imaging & treatment of moving targets
Past activityTumours in the thorax and abdomen move with every breath, posing a fundamental challenge for the precision of proton therapy. Our work addressed this problem through the development of 4D imaging pipelines, real-time tumour tracking, and adaptive delivery strategies for pencil beam scanning. This body of work produced new tools for motion capture and characterisation, 4D dose calculation, and beam delivery optimisation.
Funding
New concept for adaptive real-time tumour tracking
In radiotherapy, the most efficient way to treat a tumour that moves as a result of patient breathing is tracking its position with the treatment beam. The translation of this approach to particle therapy is challenging due to the finite range of the treatment beam and its dependence on the density of tissues crossed. This project explored the momentum acceptance and global achromaticity of a gantry beam line to perform ultra-fast and continuous energy regulation for tumour tracking.
Publications
Deformable vector fields warping for modelling of irregular breathing
A motion model-guided 4D dose reconstruction for pencil beam scanned proton therapy
Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
Retrospective reconstruction of four-dimensional magnetic resonance from interleaved cine imaging – A comparative study with four-dimensional computed tomography in the lung
Beam properties within the momentum acceptance of a clinical gantry beamline for proton therapy
Technical assessment of the NDI Polaris Vega optical tracking system
Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers
Preliminary study of the Intel RealSense D415 camera for monitoring respiratory-like motion of an irregular surface
Anthropomorphic phantom for deformable lung and liver CT and MR imaging for radiotherapy
The potential of gantry beamline large momentum acceptance for real-time tumour tracking in pencil beam scanning proton therapy
The dependence of interplay effects on the field scan direction in PBS proton therapy
The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy – An experimental study
Experimental validation of a deforming grid 4D dose calculation for PBS proton therapy
The impact of pencil beam scanning techniques on the effectiveness and efficiency of rescanning moving targets
Monitoring of breathing motion in image-guided PBS proton therapy: Comparative analysis of optical and electromagnetic technologies
Intra-fraction respiratory motion and baseline drift during breast Helical Tomotherapy
Real-time optical tracking for motion compensated irradiation with scanned particle beams at CNAO
Magnetic resonance imaging-guided versus surrogate-based motion tracking in liver radiation therapy: A prospective comparative study
Tumor tracking based on correlation models in scanned ion beam therapy: An experimental study
Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring