Giovanni Fattori

Giovanni Fattori

Senior Scientist · Center for Proton Therapy

Paul Scherrer Institute & ETH Zürich

I study how advances in data analysis, biomedical imaging, and computational modelling can improve the precision and outcomes of radiation therapy — with a focus on proton therapy.

ORCID Google Scholar LinkedIn Contact

Research

Clinical outcomes modelling

Current focus

We develop and validate predictive models of treatment response and normal tissue toxicity in patients treated with proton therapy. By integrating dosimetric data, quantitative imaging biomarkers, and clinical follow-up, we aim to understand the biological mechanisms underlying treatment outcomes and support therapeutic decisions.

NTCP modelling Survival analysis Radiomics Habitat imaging Mixed-effects models
View projects & publications →
Clinical outcomes modelling
1 active SNF project · 1 current PhD student · Thesis opportunities available
4D imaging
4D imaging & moving targets Past activity

Development of tumour tracking, 4D dose calculation, and real-time adaptive delivery for lung and abdominal cancers treated with pencil beam scanning proton therapy.

View projects & publications →
Image-guided positioning
Image-guided patient positioning Past activity

Robotic C-arm imaging system for 2D/3D registration at CNAO, and CT scout pair registration for daily patient alignment at PSI.

View projects & publications →

Latest updates

Jun 2026 B. Golomer — "Dose-LETd interaction in temporal lobe contrast enhancement among skull-base chordoma patients with high-grade toxicity" — PTCOG 64, Deauville Talk
Sep 2026 Image Guided Medical Interventions course starts at ETH Zürich Teaching
2025 DeepHealth Movement — Engineering the Future of Health — PHRT exhibition at Expo 2025 Osaka and touring Switzerland Outreach

For students

Thesis & semester projects

Master and semester projects are available in clinical outcomes modelling, MR imaging biomarkers, eye tracking for proton therapy, and medical physics. Topics span imaging, statistical modelling, and treatment planning.

See open projects →

Teaching

I teach Image Guided Medical Interventions at ETH Zürich (fall semester, course 465-0970-00L) and lecture at the Winterschool for Protons at PSI, covering imaging and technological innovation in proton therapy.

Course details →